Pesquisa | Secretaria de Estado da Saúde

1.

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron.

Gagne, Matthew; Moliva, Juan I; Foulds, Kathryn E; Andrew, Shayne F; Flynn, Barbara J; Werner, Anne P; Wagner, Danielle A; Teng, I-Ting; Lin, Bob C; Moore, Christopher; Jean-Baptiste, Nazaire; Carroll, Robin; Foster, Stephanie L; Patel, Mit; Ellis, Madison; Edara, Venkata-Viswanadh; Maldonado, Nahara Vargas; Minai, Mahnaz; McCormick, Lauren; Honeycutt, Christopher Cole; Nagata, Bianca M; Bock, Kevin W; Dulan, Caitlyn N M; Cordon, Jamilet; Flebbe, Dillon R; Todd, John-Paul M; McCarthy, Elizabeth; Pessaint, Laurent; Van Ry, Alex; Narvaez, Brandon; Valentin, Daniel; Cook, Anthony; Dodson, Alan; Steingrebe, Katelyn; Nurmukhambetova, Saule T; Godbole, Sucheta; Henry, Amy R; Laboune, Farida; Roberts-Torres, Jesmine; Lorang, Cynthia G; Amin, Shivani; Trost, Jessica; Naisan, Mursal; Basappa, Manjula; Willis, Jacquelyn; Wang, Lingshu; Shi, Wei; Doria-Rose, Nicole A; Zhang, Yi; Yang, Eun Sung.

Cell ; 185(9): 1556-1571.e18, 2022 04 28.

Artigo Inglês | MEDLINE | ID: mdl-35447072

2.

Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung.

Gagne, Matthew; Corbett, Kizzmekia S; Flynn, Barbara J; Foulds, Kathryn E; Wagner, Danielle A; Andrew, Shayne F; Todd, John-Paul M; Honeycutt, Christopher Cole; McCormick, Lauren; Nurmukhambetova, Saule T; Davis-Gardner, Meredith E; Pessaint, Laurent; Bock, Kevin W; Nagata, Bianca M; Minai, Mahnaz; Werner, Anne P; Moliva, Juan I; Tucker, Courtney; Lorang, Cynthia G; Zhao, Bingchun; McCarthy, Elizabeth; Cook, Anthony; Dodson, Alan; Teng, I-Ting; Mudvari, Prakriti; Roberts-Torres, Jesmine; Laboune, Farida; Wang, Lingshu; Goode, Adrienne; Kar, Swagata; Boyoglu-Barnum, Seyhan; Yang, Eun Sung; Shi, Wei; Ploquin, Aurélie; Doria-Rose, Nicole; Carfi, Andrea; Mascola, John R; Boritz, Eli A; Edwards, Darin K; Andersen, Hanne; Lewis, Mark G; Suthar, Mehul S; Graham, Barney S; Roederer, Mario; Moore, Ian N; Nason, Martha C; Sullivan, Nancy J; Douek, Daniel C; Seder, Robert A.

Cell ; 185(1): 113-130.e15, 2022 01 06.

Artigo Inglês | MEDLINE | ID: mdl-34921774

3.

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.

Kong, Rui; Duan, Hongying; Sheng, Zizhang; Xu, Kai; Acharya, Priyamvada; Chen, Xuejun; Cheng, Cheng; Dingens, Adam S; Gorman, Jason; Sastry, Mallika; Shen, Chen-Hsiang; Zhang, Baoshan; Zhou, Tongqing; Chuang, Gwo-Yu; Chao, Cara W; Gu, Ying; Jafari, Alexander J; Louder, Mark K; O'Dell, Sijy; Rowshan, Ariana P; Viox, Elise G; Wang, Yiran; Choi, Chang W; Corcoran, Martin M; Corrigan, Angela R; Dandey, Venkata P; Eng, Edward T; Geng, Hui; Foulds, Kathryn E; Guo, Yicheng; Kwon, Young D; Lin, Bob; Liu, Kevin; Mason, Rosemarie D; Nason, Martha C; Ohr, Tiffany Y; Ou, Li; Rawi, Reda; Sarfo, Edward K; Schön, Arne; Todd, John P; Wang, Shuishu; Wei, Hui; Wu, Winston; Mullikin, James C; Bailer, Robert T; Doria-Rose, Nicole A; Karlsson Hedestam, Gunilla B; Scorpio, Diana G; Overbaugh, Julie.

Cell ; 178(3): 567-584.e19, 2019 07 25.

Artigo Inglês | MEDLINE | ID: mdl-31348886

4.

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires.

Tian, Ming; Cheng, Cheng; Chen, Xuejun; Duan, Hongying; Cheng, Hwei-Ling; Dao, Mai; Sheng, Zizhang; Kimble, Michael; Wang, Lingshu; Lin, Sherry; Schmidt, Stephen D; Du, Zhou; Joyce, M Gordon; Chen, Yiwei; DeKosky, Brandon J; Chen, Yimin; Normandin, Erica; Cantor, Elizabeth; Chen, Rita E; Doria-Rose, Nicole A; Zhang, Yi; Shi, Wei; Kong, Wing-Pui; Choe, Misook; Henry, Amy R; Laboune, Farida; Georgiev, Ivelin S; Huang, Pei-Yi; Jain, Suvi; McGuire, Andrew T; Georgeson, Eric; Menis, Sergey; Douek, Daniel C; Schief, William R; Stamatatos, Leonidas; Kwong, Peter D; Shapiro, Lawrence; Haynes, Barton F; Mascola, John R; Alt, Frederick W.

Cell ; 166(6): 1471-1484.e18, 2016 Sep 08.

Artigo Inglês | MEDLINE | ID: mdl-27610571

5.

Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.

Chen, Xuejun; Zhou, Tongqing; Schmidt, Stephen D; Duan, Hongying; Cheng, Cheng; Chuang, Gwo-Yu; Gu, Ying; Louder, Mark K; Lin, Bob C; Shen, Chen-Hsiang; Sheng, Zizhang; Zheng, Michelle X; Doria-Rose, Nicole A; Joyce, M Gordon; Shapiro, Lawrence; Tian, Ming; Alt, Frederick W; Kwong, Peter D; Mascola, John R.

Immunity ; 54(2): 324-339.e8, 2021 02 09.

Artigo Inglês | MEDLINE | ID: mdl-33453152

6.

Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses.

Mukhamedova, Maryam; Wrapp, Daniel; Shen, Chen-Hsiang; Gilman, Morgan S A; Ruckwardt, Tracy J; Schramm, Chaim A; Ault, Larissa; Chang, Lauren; Derrien-Colemyn, Alexandrine; Lucas, Sarah A M; Ransier, Amy; Darko, Samuel; Phung, Emily; Wang, Lingshu; Zhang, Yi; Rush, Scott A; Madan, Bharat; Stewart-Jones, Guillaume B E; Costner, Pamela J; Holman, LaSonji A; Hickman, Somia P; Berkowitz, Nina M; Doria-Rose, Nicole A; Morabito, Kaitlyn M; DeKosky, Brandon J; Gaudinski, Martin R; Chen, Grace L; Crank, Michelle C; Misasi, John; Sullivan, Nancy J; Douek, Daniel C; Kwong, Peter D; Graham, Barney S; McLellan, Jason S; Mascola, John R.

Immunity ; 54(4): 769-780.e6, 2021 04 13.

Artigo Inglês | MEDLINE | ID: mdl-33823129

7.

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.

Zhou, Tongqing; Lynch, Rebecca M; Chen, Lei; Acharya, Priyamvada; Wu, Xueling; Doria-Rose, Nicole A; Joyce, M Gordon; Lingwood, Daniel; Soto, Cinque; Bailer, Robert T; Ernandes, Michael J; Kong, Rui; Longo, Nancy S; Louder, Mark K; McKee, Krisha; O'Dell, Sijy; Schmidt, Stephen D; Tran, Lillian; Yang, Zhongjia; Druz, Aliaksandr; Luongo, Timothy S; Moquin, Stephanie; Srivatsan, Sanjay; Yang, Yongping; Zhang, Baoshan; Zheng, Anqi; Pancera, Marie; Kirys, Tatsiana; Georgiev, Ivelin S; Gindin, Tatyana; Peng, Hung-Pin; Yang, An-Suei; Mullikin, James C; Gray, Matthew D; Stamatatos, Leonidas; Burton, Dennis R; Koff, Wayne C; Cohen, Myron S; Haynes, Barton F; Casazza, Joseph P; Connors, Mark; Corti, Davide; Lanzavecchia, Antonio; Sattentau, Quentin J; Weiss, Robin A; West, Anthony P; Bjorkman, Pamela J; Scheid, Johannes F; Nussenzweig, Michel C; Shapiro, Lawrence.

Cell ; 161(6): 1280-92, 2015 Jun 04.

Artigo Inglês | MEDLINE | ID: mdl-26004070

8.

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope.

Schoofs, Till; Barnes, Christopher O; Suh-Toma, Nina; Golijanin, Jovana; Schommers, Philipp; Gruell, Henning; West, Anthony P; Bach, Franziska; Lee, Yu Erica; Nogueira, Lilian; Georgiev, Ivelin S; Bailer, Robert T; Czartoski, Julie; Mascola, John R; Seaman, Michael S; McElrath, M Juliana; Doria-Rose, Nicole A; Klein, Florian; Nussenzweig, Michel C; Bjorkman, Pamela J.

Immunity ; 50(6): 1513-1529.e9, 2019 06 18.

Artigo Inglês | MEDLINE | ID: mdl-31126879

9.

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability.

Dubrovskaya, Viktoriya; Tran, Karen; Ozorowski, Gabriel; Guenaga, Javier; Wilson, Richard; Bale, Shridhar; Cottrell, Christopher A; Turner, Hannah L; Seabright, Gemma; O'Dell, Sijy; Torres, Jonathan L; Yang, Lifei; Feng, Yu; Leaman, Daniel P; Vázquez Bernat, Néstor; Liban, Tyler; Louder, Mark; McKee, Krisha; Bailer, Robert T; Movsesyan, Arlette; Doria-Rose, Nicole A; Pancera, Marie; Karlsson Hedestam, Gunilla B; Zwick, Michael B; Crispin, Max; Mascola, John R; Ward, Andrew B; Wyatt, Richard T.

Immunity ; 51(5): 915-929.e7, 2019 11 19.

Artigo Inglês | MEDLINE | ID: mdl-31732167

10.

Defining the risk of SARS-CoV-2 variants on immune protection.

DeGrace, Marciela M; Ghedin, Elodie; Frieman, Matthew B; Krammer, Florian; Grifoni, Alba; Alisoltani, Arghavan; Alter, Galit; Amara, Rama R; Baric, Ralph S; Barouch, Dan H; Bloom, Jesse D; Bloyet, Louis-Marie; Bonenfant, Gaston; Boon, Adrianus C M; Boritz, Eli A; Bratt, Debbie L; Bricker, Traci L; Brown, Liliana; Buchser, William J; Carreño, Juan Manuel; Cohen-Lavi, Liel; Darling, Tamarand L; Davis-Gardner, Meredith E; Dearlove, Bethany L; Di, Han; Dittmann, Meike; Doria-Rose, Nicole A; Douek, Daniel C; Drosten, Christian; Edara, Venkata-Viswanadh; Ellebedy, Ali; Fabrizio, Thomas P; Ferrari, Guido; Fischer, Will M; Florence, William C; Fouchier, Ron A M; Franks, John; García-Sastre, Adolfo; Godzik, Adam; Gonzalez-Reiche, Ana Silvia; Gordon, Aubree; Haagmans, Bart L; Halfmann, Peter J; Ho, David D; Holbrook, Michael R; Huang, Yaoxing; James, Sarah L; Jaroszewski, Lukasz; Jeevan, Trushar; Johnson, Robert M.

Nature ; 605(7911): 640-652, 2022 05.

Artigo Inglês | MEDLINE | ID: mdl-35361968

11.

Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.

Cale, Evan M; Gorman, Jason; Radakovich, Nathan A; Crooks, Ema T; Osawa, Keiko; Tong, Tommy; Li, Jiaqi; Nagarajan, Raju; Ozorowski, Gabriel; Ambrozak, David R; Asokan, Mangai; Bailer, Robert T; Bennici, Anthony K; Chen, Xuejun; Doria-Rose, Nicole A; Druz, Aliaksandr; Feng, Yu; Joyce, M Gordon; Louder, Mark K; O'Dell, Sijy; Oliver, Courtney; Pancera, Marie; Connors, Mark; Hope, Thomas J; Kepler, Thomas B; Wyatt, Richard T; Ward, Andrew B; Georgiev, Ivelin S; Kwong, Peter D; Mascola, John R; Binley, James M.

Immunity ; 46(5): 777-791.e10, 2017 05 16.

Artigo Inglês | MEDLINE | ID: mdl-28514685

12.

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness.

Corbett, Kizzmekia S; Edwards, Darin K; Leist, Sarah R; Abiona, Olubukola M; Boyoglu-Barnum, Seyhan; Gillespie, Rebecca A; Himansu, Sunny; Schäfer, Alexandra; Ziwawo, Cynthia T; DiPiazza, Anthony T; Dinnon, Kenneth H; Elbashir, Sayda M; Shaw, Christine A; Woods, Angela; Fritch, Ethan J; Martinez, David R; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; Hutchinson, Geoffrey B; Wu, Kai; Henry, Carole; Bahl, Kapil; Garcia-Dominguez, Dario; Ma, LingZhi; Renzi, Isabella; Kong, Wing-Pui; Schmidt, Stephen D; Wang, Lingshu; Zhang, Yi; Phung, Emily; Chang, Lauren A; Loomis, Rebecca J; Altaras, Nedim Emil; Narayanan, Elisabeth; Metkar, Mihir; Presnyak, Vlad; Liu, Cuiping; Louder, Mark K; Shi, Wei; Leung, Kwanyee; Yang, Eun Sung; West, Ande; Gully, Kendra L; Stevens, Laura J; Wang, Nianshuang; Wrapp, Daniel; Doria-Rose, Nicole A; Stewart-Jones, Guillaume; Bennett, Hamilton.

Nature ; 586(7830): 567-571, 2020 10.

Artigo Inglês | MEDLINE | ID: mdl-32756549

13.

HIV Immunology Goes Out On a Limb.

Doria-Rose, Nicole A; Mascola, John R.

Immunity ; 44(5): 1088-90, 2016 05 17.

Artigo Inglês | MEDLINE | ID: mdl-27192575

14.

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

Huang, Jinghe; Kang, Byong H; Ishida, Elise; Zhou, Tongqing; Griesman, Trevor; Sheng, Zizhang; Wu, Fan; Doria-Rose, Nicole A; Zhang, Baoshan; McKee, Krisha; O'Dell, Sijy; Chuang, Gwo-Yu; Druz, Aliaksandr; Georgiev, Ivelin S; Schramm, Chaim A; Zheng, Anqi; Joyce, M Gordon; Asokan, Mangaiarkarasi; Ransier, Amy; Darko, Sam; Migueles, Stephen A; Bailer, Robert T; Louder, Mark K; Alam, S Munir; Parks, Robert; Kelsoe, Garnett; Von Holle, Tarra; Haynes, Barton F; Douek, Daniel C; Hirsch, Vanessa; Seaman, Michael S; Shapiro, Lawrence; Mascola, John R; Kwong, Peter D; Connors, Mark.

Immunity ; 45(5): 1108-1121, 2016 11 15.

Artigo Inglês | MEDLINE | ID: mdl-27851912

15.

Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization.

Sastry, Mallika; Changela, Anita; Gorman, Jason; Xu, Kai; Chuang, Gwo-Yu; Shen, Chen-Hsiang; Cheng, Cheng; Geng, Hui; O'Dell, Sijy; Ou, Li; Rawi, Reda; Reveiz, Mateo; Stewart-Jones, Guillaume B E; Wang, Shuishu; Zhang, Baoshan; Zhou, Tongqing; Biju, Andrea; Chambers, Michael; Chen, Xuejun; Corrigan, Angela R; Lin, Bob C; Louder, Mark K; McKee, Krisha; Nazzari, Alexandra F; Olia, Adam S; Parchment, Danealle K; Sarfo, Edward K; Stephens, Tyler; Stuckey, Jonathan; Tsybovsky, Yaroslav; Verardi, Raffaello; Wang, Yiran; Zheng, Cheng-Yan; Chen, Yuling; Doria-Rose, Nicole A; McDermott, Adrian B; Mascola, John R; Kwong, Peter D.

J Virol ; 97(5): e0160422, 2023 05 31.

Artigo Inglês | MEDLINE | ID: mdl-37098956

16.

Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4.

Welles, Hugh C; King, Hannah A D; Nettey, Leonard; Cavett, Nicole; Gorman, Jason; Zhou, Tongqing; Tsybovsky, Yaroslav; Du, Renguang; Song, Kaimei; Nguyen, Richard; Ambrozak, David; Ransier, Amy; Schramm, Chaim A; Doria-Rose, Nicole A; Swanstrom, Adrienne E; Hoxie, James A; LaBranche, Celia; Montefiori, David C; Douek, Daniel C; Kwong, Peter D; Mascola, John R; Roederer, Mario; Mason, Rosemarie D.

PLoS Pathog ; 18(6): e1010574, 2022 06.

Artigo Inglês | MEDLINE | ID: mdl-35709309

17.

Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody.

Madan, Bharat; Zhang, Baoshan; Xu, Kai; Chao, Cara W; O'Dell, Sijy; Wolfe, Jacy R; Chuang, Gwo-Yu; Fahad, Ahmed S; Geng, Hui; Kong, Rui; Louder, Mark K; Nguyen, Thuy Duong; Rawi, Reda; Schön, Arne; Sheng, Zizhang; Nimrania, Rajani; Wang, Yiran; Zhou, Tongqing; Lin, Bob C; Doria-Rose, Nicole A; Shapiro, Lawrence; Kwong, Peter D; DeKosky, Brandon J.

Proc Natl Acad Sci U S A ; 118(10)2021 03 09.

Artigo Inglês | MEDLINE | ID: mdl-33649208

18.

Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2.

Cale, Evan M; Driscoll, Jefferson I; Lee, Myungjin; Gorman, Jason; Zhou, Tongqing; Lu, Maolin; Geng, Hui; Lai, Yen-Ting; Chuang, Gwo-Yu; Doria-Rose, Nicole A; Mothes, Walther; Kwong, Peter D; Mascola, John R.

J Biol Chem ; 298(4): 101819, 2022 04.

Artigo Inglês | MEDLINE | ID: mdl-35283191

19.

An mRNA Vaccine against SARS-CoV-2 - Preliminary Report.

Jackson, Lisa A; Anderson, Evan J; Rouphael, Nadine G; Roberts, Paul C; Makhene, Mamodikoe; Coler, Rhea N; McCullough, Michele P; Chappell, James D; Denison, Mark R; Stevens, Laura J; Pruijssers, Andrea J; McDermott, Adrian; Flach, Britta; Doria-Rose, Nicole A; Corbett, Kizzmekia S; Morabito, Kaitlyn M; O'Dell, Sijy; Schmidt, Stephen D; Swanson, Phillip A; Padilla, Marcelino; Mascola, John R; Neuzil, Kathleen M; Bennett, Hamilton; Sun, Wellington; Peters, Etza; Makowski, Mat; Albert, Jim; Cross, Kaitlyn; Buchanan, Wendy; Pikaart-Tautges, Rhonda; Ledgerwood, Julie E; Graham, Barney S; Beigel, John H.

N Engl J Med ; 383(20): 1920-1931, 2020 11 12.

Artigo Inglês | MEDLINE | ID: mdl-32663912

20.

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults.

Anderson, Evan J; Rouphael, Nadine G; Widge, Alicia T; Jackson, Lisa A; Roberts, Paul C; Makhene, Mamodikoe; Chappell, James D; Denison, Mark R; Stevens, Laura J; Pruijssers, Andrea J; McDermott, Adrian B; Flach, Britta; Lin, Bob C; Doria-Rose, Nicole A; O'Dell, Sijy; Schmidt, Stephen D; Corbett, Kizzmekia S; Swanson, Phillip A; Padilla, Marcelino; Neuzil, Kathy M; Bennett, Hamilton; Leav, Brett; Makowski, Mat; Albert, Jim; Cross, Kaitlyn; Edara, Venkata Viswanadh; Floyd, Katharine; Suthar, Mehul S; Martinez, David R; Baric, Ralph; Buchanan, Wendy; Luke, Catherine J; Phadke, Varun K; Rostad, Christina A; Ledgerwood, Julie E; Graham, Barney S; Beigel, John H.

N Engl J Med ; 383(25): 2427-2438, 2020 12 17.

Artigo Inglês | MEDLINE | ID: mdl-32991794

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